| http://purl.uniprot.org/citations/18607539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18607539 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutral endopeptidase (NEP), which degrades substance P (SP), may regulate neutrophil activation during Mg-deficiency (MgD). Male Sprague-Dawley rats (180g) were fed MgD (approximately 50 mg Mg/kg) or Mg-sufficient (MgS, 608 mg Mg/kg) diets for 7 days +/-NEP inhibitor phosphoramidon (PR, 5 mg/kg/day, s.c.). MgD alone induced a 9-fold (vs. MgS, p <0.01) elevation in plasma SP; MgD+PR enhanced it further to 18-fold (p <0.001). Neutrophils from MgD+PR rats displayed a 3.9-fold higher (p <0.01) basal .O(2-) generation, but those from MgD or PR alone were not activated. Plasma PGE2-metabolite levels rose 2.67- (p <0.01) and 1.56-(p <0.05) fold, respectively, in MgD+PR and MgD groups; the corresponding red blood cell glutathione levels were decreased 21% (p <0.025) and 7% (NS). MgD+PR significantly reduced neutrophil NEP activity by 48% (p <0.02); PR or MgD alone only reduced this activity 26% and 15%, respectively. We conclude that NEP inhibition potentiates SP-mediated neutrophil .O(2-) production and may promote other inflammatory activities during MgD."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00011-007-7186-z"xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/author | "Kramer J.H."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/author | "Mak I.T."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/author | "Weglicki W.B."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/author | "Chmielinska J.J."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/author | "Khalid M.H."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/author | "Landgraf K.M."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/name | "Inflamm Res"xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/pages | "300-305"xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/title | "Inhibition of neutral endopeptidase potentiates neutrophil activation during Mg-deficiency in the rat."xsd:string |
| http://purl.uniprot.org/citations/18607539 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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