| http://purl.uniprot.org/citations/18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18611861 | http://www.w3.org/2000/01/rdf-schema#comment | "In both invertebrates and vertebrates, transcriptional co-repressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate a number of developmental mechanisms, including neuronal differentiation. The pleiotropic activity of Gro/TLE depends on context-specific interactions with a variety of DNA-binding proteins. Most of those factors engage Gro/TLE through two different types of short peptide motifs, the WRP(W/Y) tetrapeptide and the Engrailed homology 1 (Eh1) sequence (FXIXXIL). The aim of this study was to elucidate the contribution of WRP(W/Y) and Eh1 motifs to mammalian Gro/TLE anti-neurogenic activity. Here we describe point mutations within the C-terminal WD40 repeat domain of Gro/TLE1 that do not perturb protein folding but disrupt the ability of Gro/TLE1 to inhibit the differentiation of cerebral cortex neural progenitor cells into neurons. One of those mutations, L743F, selectively blocks binding to Hes1, an anti-neurogenic basic helix-loop-helix protein that harbors a WRPW motif. In contrast, the L743F mutation does not disrupt binding to Engrailed1 and FoxG1, which both contain Eh1 motifs, nor to Tcf3, which binds to the Gro/TLE N terminus. These results demonstrate that the recruitment of transcription factors harboring WRP(W/Y) tetrapeptides is essential to the anti-neurogenic function of Gro/TLE1."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800722200"xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/author | "Stifani S."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/author | "Brickman J.M."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/author | "Laing A."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/author | "Buscarlet M."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/author | "Perin A."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/pages | "24881-24888"xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/title | "Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides."xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18611861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18611861 |
| http://purl.uniprot.org/citations/18611861 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18611861 |
| http://purl.uniprot.org/uniprot/#_B4DEF9-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_B4E345-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q62440-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q04724-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q59EF7-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q5SQA2-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q5SQA3-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q5SQA4-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q6PFG2-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |
| http://purl.uniprot.org/uniprot/#_Q6YL43-mappedCitation-18611861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18611861 |