| http://purl.uniprot.org/citations/18617636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18617636 | http://www.w3.org/2000/01/rdf-schema#comment | "The partial tandem duplication of MLL (MLL-PTD) is found in 5% to 10% of patients with acute myeloid leukemia (AML) and normal cytogenetics. Its expression in leukemic blasts is coincident with a silenced wild-type (WT) MLL allele. We therefore generated mice expressing the Mll-PTD in the absence of Mll-WT. These Mll(PTD/-) mice die at birth unlike the normal life expectancy of Mll(PTD/WT), Mll(WT/-), and Mll(WT/WT) mice. Using Mll(WT/WT) fetal liver cells (FLC) as baseline, we compared Mll(PTD/-) with Mll(PTD/WT) FLC and found both had increased HoxA gene expression and granulocyte-macrophage colony-forming progenitor cells (CFU-GM); in contrast, only Mll(PTD/WT) FLC had increased pluripotent hemopoietic progenitors (CFU-GEMM). The similarities between Mll(PTD/WT) and Mll(PTD/-) mice suggest that the Mll-PTD mutation can up-regulate target genes in a dominant, gain-of-function fashion. The differences between these 2 genotypes suggest that in select tissues the Mll-PTD requires cooperation with the Mll-WT in the genesis of the observed abnormality."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-01-134338"xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Chang D."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Yuan W."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Caligiuri M.A."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Marcucci G."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Chong A."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Dorrance A.M."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Guimond M."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Whitman S.P."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Nemer D."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/author | "Pulley B."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/pages | "2508-2511"xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/title | "The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele."xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18617636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18617636 |
| http://purl.uniprot.org/citations/18617636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18617636 |
| http://purl.uniprot.org/uniprot/#_A0A087WR88-mappedCitation-18617636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18617636 |
| http://purl.uniprot.org/uniprot/#_D3Z5H5-mappedCitation-18617636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18617636 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQS9-mappedCitation-18617636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18617636 |
| http://purl.uniprot.org/uniprot/#_G3UZS1-mappedCitation-18617636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18617636 |