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http://purl.uniprot.org/citations/18618252http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18618252http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The purpose was to investigate single nucleotide polymorphism of the vitamin D receptor gene and its possible relationship with colorectal cancer (CRC) in a Chinese population.

Methods

The vitamin D receptor (VDR) genotypes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) using endonuclease BsmI and FokI, and direct sequencing in 400 Chinese people, comprised of 200 CRC patients and 200 controls from the same area in China.

Results

The distribution of alleles (F/f) and genotypes (FF/Ff/ff) of the FokI had no significant difference between CRC patients and normal controls (P > 0.05), while that of the B allele and the BB genotype of the BsmI in CRC patients was significantly lower compared with the control group (0.1625 versus 0.740, P < 0.05, OR = 0.068, 95% CI: 0.048-0.096 and 0.060 versus 0.590, P < 0.05, OR = 0.015, 95% CI: 0.007-0.032).

Conclusion

The BB genotype of the VDR BsmI variant was significantly associated with a decreased risk of CRC in a Chinese population, while the VDR FokI polymorphism was not significantly associated with it."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.org/dc/terms/identifier"doi:10.1007/s10620-008-0375-y"xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Zhang L."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Zhou B."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Wang Y.Y."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Lu H.M."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Lv M.L."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/author"Gao L.B."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/name"Dig Dis Sci"xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/pages"634-639"xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/title"Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population."xsd:string
http://purl.uniprot.org/citations/18618252http://purl.uniprot.org/core/volume"54"xsd:string
http://purl.uniprot.org/citations/18618252http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18618252
http://purl.uniprot.org/citations/18618252http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18618252
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http://purl.uniprot.org/uniprot/#_B4DRV7-mappedCitation-18618252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18618252
http://purl.uniprot.org/uniprot/#_B6ZGT0-mappedCitation-18618252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18618252
http://purl.uniprot.org/uniprot/#_F1D8P8-mappedCitation-18618252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18618252
http://purl.uniprot.org/uniprot/#_P11473-mappedCitation-18618252http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18618252
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