| http://purl.uniprot.org/citations/18620489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18620489 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied in vitro production of interferon-gamma and expression of interferon-gamma receptors (R1 and R2) by the peripheral blood mononuclear cells of 24 HIV-1-infected patients and 12 healthy volunteers. Interferon-gamma production was lower in HIV-1-infected patients compared with healthy volunteers (p < 0.05), and it further declined in patients with lower CD4+ T-cell counts. In contrast, expression of interferon-gamma R1 by CD4+ T lymphocytes was higher in HIV-infected patients than healthy volunteers (25% versus 10%, p < 0.05). In the HIV-infected group, interferon-gamma R1 expression increased with a decline in CD4+ T-cell count (r = -0.64, p < 0.001). Interferon-gamma R2 expression directly correlated with interferon-gamma R1 expression (p < 0.001). When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC). In conclusion, with progression of HIV-1 infection, interferon-gamma production declines whereas expression of interferon-gamma receptors (R1 and R2) increases. Persistent upregulation of both interferon-gamma R1 and R2 receptors probably favors development of type 2 T-helper cells environment and promotes viral replication. This dysfunction in the interferon-gamma pathway contributes to a further impairment in cellular immune function in patients with advanced HIV-1 infection, which may further increase susceptibility to opportunistic infections."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.org/dc/terms/identifier | "doi:10.1089/aid.2007.0261"xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Koch L."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "El-Azizi M."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Stueber D."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Ghassemi M."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Novak R.M."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Adamski A."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Khardori N.M."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/author | "Koirala J."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/name | "AIDS Res Hum Retroviruses"xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/pages | "1097-1102"xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/title | "Interferon-gamma receptors in HIV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/18620489 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18620489 |
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| http://purl.uniprot.org/uniprot/#_A8K881-mappedCitation-18620489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18620489 |