| http://purl.uniprot.org/citations/18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18622390 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal communication is mediated by Ca(2+)-triggered fusion of transmitter-filled synaptic vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca(2+) sensor that regulates exocytosis, whereas soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins in the vesicle and target membrane assemble into complexes that directly catalyze bilayer fusion. Here we report that, before the Ca(2+) trigger, synaptotagmin interacts with SNARE proteins in the target membrane to halt SNARE complex assembly at a step after donor vesicles attach, or dock, to target membranes. This results in fusion complexes that, when subsequently triggered by Ca(2+), drive rapid, highly efficient lipid mixing. Ca(2+)-independent interactions with SNAREs also predispose synaptotagmin to selectively penetrate the target membrane in response to Ca(2+); we demonstrate that Ca(2+)-synaptotagmin must insert into the target membrane to accelerate SNARE-catalyzed fusion. These findings demonstrate that Ca(2+) converts synaptotagmin from a clamp to a trigger for exocytosis."xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1463"xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/author | "Chapman E.R."xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/author | "Chicka M.C."xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/author | "Hui E."xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/pages | "827-835"xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/title | "Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+."xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/18622390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18622390 |
| http://purl.uniprot.org/citations/18622390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18622390 |
| http://purl.uniprot.org/uniprot/#_A6IGE2-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_P21707-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_H6RXZ1-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_Q707P0-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_Q707P1-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_Q707P2-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_Q707P4-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_P46096-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/#_Q3TPT3-mappedCitation-18622390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/P21707 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18622390 |
| http://purl.uniprot.org/uniprot/Q707P1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18622390 |