| http://purl.uniprot.org/citations/18624772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18624772 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidation and glycation of low-density lipoprotein (LDL) promote vascular injury in diabetes; however, the mechanisms underlying this effect remain poorly defined. The present study was conducted to determine the effects of 'heavily oxidized' glycated LDL (HOG-LDL) on endothelial nitric oxide synthase (eNOS) function. Exposure of bovine aortic endothelial cells with HOG-LDL reduced eNOS protein levels in a concentration- and time-dependent manner, without altering eNOS mRNA levels. Reduced eNOS protein levels were accompanied by an increase in intracellular Ca(2+), augmented production of reactive oxygen species (ROS) and induction of Ca(2+)-dependent calpain activity. Neither eNOS reduction nor any of these other effects were observed in cells exposed to native LDL. Reduction of intracellular Ca(2+) levels abolished eNOS reduction by HOG-LDL, as did pharmacological or genetic through calcium channel blockers or calcium chelator BAPTA or inhibition of NAD(P)H oxidase (with apocynin) or inhibition of calpain (calpain 1-specific siRNA). Consistent with these results, HOG-LDL impaired acetylcholine-induced endothelium-dependent vasorelaxation of isolated mouse aortas, and pharmacological inhibition of calpain prevented this effect. HOG-LDL may impair endothelial function by inducing calpain-mediated eNOS degradation in a ROS- and Ca(2+)-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1582-4934.2008.00416.x"xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Wilson K."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Xie Z."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Song P."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Zou M.H."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/author | "Lyons T."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/pages | "2899-2910"xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/title | "Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase."xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/18624772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18624772 |
| http://purl.uniprot.org/citations/18624772 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18624772 |
| http://purl.uniprot.org/uniprot/#_A0A090N8H8-mappedCitation-18624772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18624772 |
| http://purl.uniprot.org/uniprot/#_A0A3Q1LSD1-mappedCitation-18624772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18624772 |
| http://purl.uniprot.org/uniprot/#_A0S0A6-mappedCitation-18624772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18624772 |