| http://purl.uniprot.org/citations/18625844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18625844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18625844 | http://www.w3.org/2000/01/rdf-schema#comment | "Deadenylation is the major step triggering mammalian mRNA decay. One consequence of deadenylation is the formation of nontranslatable messenger RNA (mRNA) protein complexes (messenger ribonucleoproteins [mRNPs]). Nontranslatable mRNPs may accumulate in P-bodies, which contain factors involved in translation repression, decapping, and 5'-to-3' degradation. We demonstrate that deadenylation is required for mammalian P-body formation and mRNA decay. We identify Pan2, Pan3, and Caf1 deadenylases as new P-body components and show that Pan3 helps recruit Pan2, Ccr4, and Caf1 to P-bodies. Pan3 knockdown causes a reduction of P-bodies and has differential effects on mRNA decay. Knocking down Caf1 or overexpressing a Caf1 catalytically inactive mutant impairs deadenylation and mRNA decay. P-bodies are not detected when deadenylation is blocked and are restored when the blockage is released. When deadenylation is impaired, P-body formation is not restorable, even when mRNAs exit the translating pool. These results support a dynamic interplay among deadenylation, mRNP remodeling, and P-body formation in selective decay of mammalian mRNA."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200801196"xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200801196"xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Shyu A.B."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Shyu A.B."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Ezzeddine N."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/author | "Ezzeddine N."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/pages | "89-101"xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/pages | "89-101"xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/title | "Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/18625844 | http://purl.uniprot.org/core/title | "Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells."xsd:string |