DESCRIBE <http://purl.uniprot.org/citations/18626620>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18626620	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18626620	http://www.w3.org/2000/01/rdf-schema#comment	" Background The diagnosis of Creutzfeldt-Jakob disease (CJD) is based on typical clinical features and can be supported by detection of 14-3-3 protein in the CSF. The present study suggests the importance of investigating this ratio of total tau protein to phosphorylated tau protein in differentiating CJD from other dementias. Thirty-one patients with Alzheimer's disease (AD) or frontotemporal dementia and four with definitive diagnoses of CJD were included in the study. Methods and material Results from baseline investigations were compared with those from an age-matched cognitively controlled group with Bell's palsy. Tau protein, phosphorylated tau protein, and beta amyloid were analyzed using a commercially available enzyme-linked immunosorbent assay; 14-3-3 protein was assessed by Western blotting. Results and conclusion A distinctly high proportion of total tau protein to phosphorylated tau protein in CSF was found in all patients diagnosed with CJD, even in those with negative 14-3-3 protein blot results. In contrast, marker analysis in patients with Alzheimer's dementia revealed the highest CSF ratio of beta amyloid to phosphorylated tau protein levels. These proteins are important diagnostic biomarkers for CJD, especially in patients with negative 14-3-3 protein findings."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.org/dc/terms/identifier	"doi:10.1007/s00115-008-2501-7"xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Hort J."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Bojar M."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Vyhnalek M."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Valis M."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Glossova L."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Masopust J."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Skoda D."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Stourac P."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Talab R."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/author	"Waberzinek G."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/name	"Nervenarzt"xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/pages	"891-892"xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/title	"[Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia]."xsd:string
http://purl.uniprot.org/citations/18626620	http://purl.uniprot.org/core/volume	"79"xsd:string
http://purl.uniprot.org/citations/18626620	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18626620
http://purl.uniprot.org/citations/18626620	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18626620
http://purl.uniprot.org/uniprot/#_B4DMT8-mappedCitation-18626620	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18626620
http://purl.uniprot.org/uniprot/#_B4DY04-mappedCitation-18626620	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18626620
http://purl.uniprot.org/uniprot/#_P27348-mappedCitation-18626620	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18626620
http://purl.uniprot.org/uniprot/#_Q53RR5-mappedCitation-18626620	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18626620
http://purl.uniprot.org/uniprot/#_Q53S41-mappedCitation-18626620	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18626620