| http://purl.uniprot.org/citations/18627265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18627265 | http://www.w3.org/2000/01/rdf-schema#comment | "It is well established that calcitonin is a potent inhibitor of bone resorption; however, a physiological role for calcitonin acting through its cognate receptor, the calcitonin receptor (CTR), has not been identified. Data from previous genetically modified animal models have recognized a possible role for calcitonin and the CTR in controlling bone formation; however, interpretation of these data are complicated, in part because of their mixed genetic background. Therefore, to elucidate the physiological role of the CTR in calcium and bone metabolism, we generated a viable global CTR knockout (KO) mouse model using the Cre/loxP system, in which the CTR is globally deleted by >94% but <100%. Global CTRKOs displayed normal serum ultrafiltrable calcium levels and a mild increase in bone formation in males, showing that the CTR plays a modest physiological role in the regulation of bone and calcium homeostasis in the basal state in mice. Furthermore, the peak in serum total calcium after calcitriol [1,25(OH)(2)D(3)]-induced hypercalcemia was substantially greater in global CTRKOs compared with controls. These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.org/dc/terms/identifier | "doi:10.1359/jbmr.080310"xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Ma C."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Davey R.A."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Vincent C."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Atkins G.J."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Findlay D.M."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Moore A.J."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "McManus J.F."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "MacLean H.E."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Morris H.A."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Anderson P.H."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Zajac J.D."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Glatt V."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Turner A.G."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Chiu W.S."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Bouxsein M."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/author | "Tjahyono F."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/pages | "1182-1193"xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/title | "Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice."xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/18627265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18627265 |