| http://purl.uniprot.org/citations/18627437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18627437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18627437 | http://www.w3.org/2000/01/rdf-schema#comment | "In a search for sweet taste receptor interacting proteins, we have identified the calcium- and integrin-binding protein 1 (CIB1) as specific binding partner of the intracellular carboxyterminal domain of the rat sweet taste receptor subunit Tas1r2. In heterologous human embryonic kidney 293 (HEK293) cells, the G protein chimeras Galpha(16gust44) and Galpha(15i3) link the sweet taste receptor dimer TAS1R2/TAS1R3 to an inositol 1,4,5-trisphosphate (InsP3)-dependent Ca2+ release pathway. To demonstrate the influence of CIB1 on the cytosolic Ca2+ concentration, we used sweet and umami compounds as well as other InsP3-generating ligands in FURA-2-based Ca2+ assays in wild-type HEK293 cells and HEK293 cells expressing functional human sweet and umami taste receptor dimers. Stable and transient depletion of CIB1 by short-hairpin RNA increased the Ca2+ response of HEK293 cells to the InsP3-generating ligands ATP, UTP and carbachol. Over-expression of CIB1 had the opposite effect as shown for the sweet ligand saccharin, the umami receptor ligand monosodium glutamate and UTP. The CIB1 effect was dependent on the thapsigargin-sensitive Ca2+ store of the endoplasmic reticulum (ER) and independent of extracellular Ca2+. The function of CIB1 on InsP3-evoked Ca2+ release from the ER is most likely mediated by its interaction with the InsP3 receptor. Thus, CIB1 seems to be an inhibitor of InsP3-dependent Ca2+ release in vivo."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2008.05563.x"xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2008.05563.x"xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Meyerhof W."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Meyerhof W."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Walter B."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Walter B."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Burhenne N."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Burhenne N."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Hennigs J.K."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Hennigs J.K."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Schmale H."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Schmale H."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Staehler F."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Staehler F."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Winnig M."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/author | "Winnig M."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/pages | "2249-2262"xsd:string |
| http://purl.uniprot.org/citations/18627437 | http://purl.uniprot.org/core/pages | "2249-2262"xsd:string |