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http://purl.uniprot.org/citations/18632168http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18632168http://www.w3.org/2000/01/rdf-schema#comment"

Background

There is accumulating evidence that transient exercise-induced ischemia triggers the release of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of this study was to either confirm or refute a previous investigation suggesting that myocardial ischemia can reliably be detected by exercise-induced changes in BNP or NT-proBNP levels in selected patients.

Methods

A total of 139 consecutive patients with normal left ventricular function and normal resting BNP and NT-proBNP levels referred for rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) were analyzed. Levels of BNP and NT-proBNP were determined before and immediately after symptom-limited bicycle ergometry.

Results

Inducible myocardial ischemia on perfusion images was detected in 46 patients (33%). Median exercise-induced increases in BNP (DeltaBNP) and NT-proBNP (DeltaNT-proBNP) were similar in patients with and without inducible ischemia (DeltaBNP 12.7 pg/ml vs. 9.4 pg/ml, p=0.109; DeltaNT-proBNP 7 pg/ml vs. 6 pg/ml, p=0.309). The area under the receiver operating characteristic curve for the ability to detect myocardial ischemia was 0.583 (95% CI, 0.479-0.688) for DeltaBNP, and 0.553 (95% CI, 0.450-0.656) for DeltaNT-proBNP.

Conclusions

Exercise-induced changes in BNP and NT-proBNP do not reliably detect myocardial ischemia in selected patients."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.org/dc/terms/identifier"doi:10.1016/j.ijcard.2008.04.024"xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Mueller C."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Christ M."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Taegtmeyer A."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Breidthardt T."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Freidank H."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Jauslin D."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Mueller-Brand J."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Staub D."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/author"Zellweger M.J."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/name"Int J Cardiol"xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/pages"40-46"xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/title"Use of changes in B-type natriuretic peptides to detect ischemia in selected patients."xsd:string
http://purl.uniprot.org/citations/18632168http://purl.uniprot.org/core/volume"136"xsd:string
http://purl.uniprot.org/citations/18632168http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18632168
http://purl.uniprot.org/citations/18632168http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18632168
http://purl.uniprot.org/uniprot/#_P16860-mappedCitation-18632168http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18632168
http://purl.uniprot.org/uniprot/P16860http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18632168