| http://purl.uniprot.org/citations/18632797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18632797 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study was performed to test the hypothesis that under normal physiological conditions and/or during augmentation of kinin levels, intrarenal kinins act on medullary bradykinin B(2) (BKB(2)) receptors to acutely increase papillary blood flow (PBF) and therefore Na(+) excretion. We determined the effect of acute inner medullary interstitial (IMI) BKB(2) receptor blockade on renal hemodynamics and excretory function in rats fed either a normal (0.23%)- or a low (0.08%)-NaCl diet. For each NaCl diet, two groups of rats were studied. Baseline renal hemodynamic and excretory function were determined during IMI infusion of 0.9% NaCl into the left kidney. The infusion was then either changed to HOE-140 (100 microg.kg(-1).h(-1), treated group) or maintained with 0.9% NaCl (time control group), and the parameters were again determined. In rats fed a normal-salt diet, HOE-140 infusion decreased left kidney Na(+) excretion (urinary Na(+) extraction rate) and fractional Na(+) excretion by 40 +/-5% and 40 +/-4%, respectively (P < 0.01), but did not alter glomerular filtration rate, inner medullary blood flow (PBF), or cortical blood flow. In rats fed a low-salt diet, HOE-140 infusion did not alter renal regional hemodynamics or excretory function. We conclude that in rats fed a normal-salt diet, kinins act tonically via medullary BKB(2) receptors to increase Na(+) excretion independent of changes in inner medullary blood flow."xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.90225.2008"xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/author | "Fitzgibbon W.R."xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/author | "Ploth D.W."xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/author | "Sivritas S.H."xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/pages | "F811-7"xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/title | "Blockade of renal medullary bradykinin B2 receptors increases tubular sodium reabsorption in rats fed a normal-salt diet."xsd:string |
| http://purl.uniprot.org/citations/18632797 | http://purl.uniprot.org/core/volume | "295"xsd:string |
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