| http://purl.uniprot.org/citations/18635804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18635804 | http://www.w3.org/2000/01/rdf-schema#comment | "When intracellular pathogens invade mammalian hosts, naïve CD8+ T cells differentiate into cytotoxic killers, which lyse infected target cells and secrete cytokines that activate intracellular microbicides. We show that CD8+ T cells deficient in the transcription factors T-bet and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus. Instead, virus-specific CD8+ T cells lacking both T-bet and Eomes differentiate into an interleukin-17-secreting lineage, reminiscent of the helper T cell fate that has been implicated in autoimmunity and extracellular microbial defense. Upon viral infection, mice with T cells lacking both T-bet and Eomes develop a CD8+ T cell-dependent, progressive inflammatory and wasting syndrome characterized by multi-organ infiltration of neutrophils. T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1159806"xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Shin H."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Lindsten T."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Banerjee A."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Hunter C.A."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Takemoto N."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Wherry E.J."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Reiner S.L."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Gordon S.M."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Intlekofer A.M."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/author | "Dejong C.S."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/pages | "408-411"xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/title | "Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin."xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://purl.uniprot.org/core/volume | "321"xsd:string |
| http://purl.uniprot.org/citations/18635804 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18635804 |
| http://purl.uniprot.org/citations/18635804 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18635804 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-18635804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18635804 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-18635804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18635804 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-18635804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18635804 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-18635804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18635804 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-18635804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18635804 |