| http://purl.uniprot.org/citations/18638657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18638657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18638657 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor-1alpha (HIF-1alpha) is critical not only in the regulation of oxygen homeostasis but also in the regulation of innate and adaptive immune systems. We previously reported that T-cell receptor-mediated activation of T cells in mice leads to the expression of an alternative isoform of HIF-1alpha that inhibits activated T cells in a delayed negative feed-back manner. In this paper, we describe a novel mRNA isoform of human HIF-1alpha that is upregulated in peripheral T lymphocytes after T-cell receptor stimulation. This activation-inducible isoform is expressed using the alternative first exon I.3, and it encodes a protein that is 24 amino acids longer than the ubiquitous HIF-1alpha isoform. This mRNA isoform I.3 of HIF-1alpha is expressed in a tissue-specific manner with the highest expression found in peripheral blood leukocytes and the thymus."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2008.05.004"xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2008.05.004"xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/author | "Lukashev D."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/author | "Lukashev D."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/author | "Sitkovsky M."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/author | "Sitkovsky M."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/name | "Hum. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/name | "Hum. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/pages | "421-425"xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/pages | "421-425"xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/title | "Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1alpha in activated human T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/title | "Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1alpha in activated human T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/18638657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18638657 |
| http://purl.uniprot.org/citations/18638657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18638657 |
| http://purl.uniprot.org/citations/18638657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18638657 |
| http://purl.uniprot.org/citations/18638657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18638657 |
| http://purl.uniprot.org/uniprot/Q16665 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18638657 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-ED9E3BB2C0590DDF195842534DCB08CE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18638657 |