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| http://purl.uniprot.org/citations/18639538 | http://www.w3.org/2000/01/rdf-schema#comment | "The Pax gene eyg is important for Drosophila eye development. eyg expression in the visual system changes dynamically during development. In this study, we found that the transcriptional regulation of eyg can be separated into four distinct temporal phases (E, L1, L2, and L3) and each is regulated by distinct cis-regulatory elements. Utilizing these enhancers for temporal and spatially specific manipulations, we addressed the regulation and function of eyg at different developmental stages. We found that Notch signaling is required and sufficient for eyg expression and this activity is restricted only to the L2 stage. We further showed that the function of eyg in eye development is required only at the second instar larval stage, while its function for head and antenna development can be provided at any time during embryo and larval development. Thus there is a temporal switch of the regulatory mechanism and function of eyg. We propose that eyg expression at L2 is induced and maintained by N signaling, and is turned off at L3 by a negative feedback loop involving the morphogenetic furrow."xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2008.06.038"xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/author | "Wang L.H."xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/author | "Sun Y.H."xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/author | "Chiu S.J."xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/pages | "515-527"xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/title | "Temporal switching of regulation and function of eye gone (eyg) in Drosophila eye development."xsd:string |
| http://purl.uniprot.org/citations/18639538 | http://purl.uniprot.org/core/volume | "321"xsd:string |
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