| http://purl.uniprot.org/citations/18641129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18641129 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18641129 | http://www.w3.org/2000/01/rdf-schema#comment | "The ESCRT machinery functions in topologically equivalent membrane fission events, namely multivesicular body formation, the terminal stages of cytokinesis and HIV-1 release. Here, we show that the ESCRT-III-binding protein Alix is recruited to the midbody of dividing cells through binding Cep55 via an evolutionarily conserved peptide. Disruption of Cep55/Alix/ESCRT-III interactions causes formation of aberrant midbodies and cytokinetic failure, demonstrating an essential role for these proteins in midbody morphology and cell division. We also show that the C terminus of Alix encodes a multimerization activity that is essential for its function in Alix-dependent HIV-1 release and for interaction with Tsg101. Last, we demonstrate that overexpression of Chmp4b and Chmp4c differentially inhibits HIV-1 release and cytokinesis, suggesting possible reasons for gene expansion within the mammalian Class E VPS pathway."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0802008105"xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0802008105"xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/author | "Agromayor M."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/author | "Agromayor M."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/author | "Martin-Serrano J."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/author | "Martin-Serrano J."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/author | "Carlton J.G."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/author | "Carlton J.G."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/pages | "10541-10546"xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/pages | "10541-10546"xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/title | "Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/title | "Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release."xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18641129 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18641129 |
| http://purl.uniprot.org/citations/18641129 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18641129 |
| http://purl.uniprot.org/citations/18641129 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18641129 |
| http://purl.uniprot.org/citations/18641129 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18641129 |