| http://purl.uniprot.org/citations/18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18641187 | http://www.w3.org/2000/01/rdf-schema#comment | "Cholesterol membrane transporters scavenger receptor class B type I (SR-BI) and (cluster determinant 36) are involved in intestinal uptake of lutein and beta-carotene, 2 of the 3 main carotenoids of the human diet. The aim of this work was therefore to determine whether SR-BI and NPC1L1 (Niemann-Pick C1-like 1), another cholesterol transporter, are implicated in absorption of lycopene, the 3rd main carotenoid of the human diet. Anti-human SR-BI antibody and block lipid transport 1 (BLT1) (a chemical inhibitor of lipid transport by SR-BI) impaired up to 60% (all-E) and (5Z)-lycopene uptake (P < 0.05) by Caco-2 cell monolayers, which were used as a model of human intestinal epithelium. The involvement of SR-BI in lycopene absorption in vivo was then verified by comparing plasma lycopene concentrations in wild-type and SR-BI transgenic mice that were fed a diet enriched with 0.25 g/kg (all-E)-lycopene for 1 mo. Plasma lycopene concentrations were approximately 10-fold higher (P < 0.001) in mice overexpressing SR-BI in the intestine than in wild-type mice, confirming the involvement of SR-BI in lycopene absorption. Further experiments showed that (all-E)-lycopene did not affect SR-BI mRNA levels in Caco-2 cells or mouse intestine. In contrast to SR-BI, neither anti-human NPC1L1 antibody nor ezetimibe, used as inhibitors of lycopene uptake via NPC1L1, significantly impaired (all-E) or (5Z)-lycopene uptake by Caco-2 monolayers. Thus, the present data show that lycopene absorption is, at least in part, mediated by SR-BI but not by NPC1L1."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.org/dc/terms/identifier | "doi:10.1093/jn/138.8.1432"xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Comera C."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Collet X."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Frohlich K."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Moussa M."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Landrier J.F."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Borel P."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Reboul E."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Ghiringhelli O."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/author | "Bohm V."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/pages | "1432-1436"xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/title | "Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1."xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/18641187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18641187 |
| http://purl.uniprot.org/citations/18641187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18641187 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGG6-mappedCitation-18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18641187 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFX6-mappedCitation-18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18641187 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3N2-mappedCitation-18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18641187 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3I2-mappedCitation-18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18641187 |
| http://purl.uniprot.org/uniprot/#_B4E3I1-mappedCitation-18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18641187 |
| http://purl.uniprot.org/uniprot/#_B4DZ71-mappedCitation-18641187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18641187 |