| http://purl.uniprot.org/citations/18641330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18641330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18641330 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell activation through the Ag receptor (TCR) requires sustained signaling from signalosomes within lipid raft microdomains in the plasma membrane. In a proteomic analysis of lipid rafts from human T cells, we identified stomatin-like protein (SLP)-2 as a candidate molecule involved in T cell activation through the Ag receptor. In this study, we show that SLP-2 expression in human primary lymphocytes is up-regulated following in vivo and ex vivo activation. In activated T cells, SLP-2 interacts with components of TCR signalosomes and with polymerized actin. More importantly, up-regulation of SLP-2 expression in human T cell lines and primary peripheral blood T cells increases effector responses, whereas down-regulation of SLP-2 expression correlates with loss of sustained TCR signaling and decreased T cell activation. Our data suggest that SLP-2 is an important player in T cell activation by ensuring sustained TCR signaling, which is required for full effector T cell differentiation, and point to SLP-2 as a potential target for immunomodulation."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.3.1927"xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.3.1927"xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Taylor R."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Taylor R."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Dustin M.L."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Dustin M.L."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Chau L.A."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Chau L.A."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Madrenas J."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Madrenas J."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Darlington P.J."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Darlington P.J."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Kirchhof M.G."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Kirchhof M.G."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Lemke C.D."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Lemke C.D."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Blanca I."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Blanca I."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Marquez M.E."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Marquez M.E."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Rizkalla K."xsd:string |
| http://purl.uniprot.org/citations/18641330 | http://purl.uniprot.org/core/author | "Rizkalla K."xsd:string |