| http://purl.uniprot.org/citations/18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18644888 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasma membrane ingression during cytokinesis involves both actin remodeling and vesicle-mediated membrane addition. Vesicle-based membrane delivery from the recycling endosome (RE) has an essential but ill-defined involvement in cytokinesis. In the Drosophila melanogaster early embryo, Nuf (Nuclear fallout), a Rab11 effector which is essential for RE function, is required for F-actin and membrane integrity during furrow ingression. We find that in nuf mutant embryos, an initial loss of F-actin at the furrow is followed by loss of the associated furrow membrane. Wild-type embryos treated with Latrunculin A or Rho inhibitor display similar defects. Drug- or Rho-GTP-induced increase of actin polymerization or genetically mediated decrease of actin depolymerization suppresses the nuf mutant F-actin and membrane defects. We also find that RhoGEF2 does not properly localize at the furrow in nuf mutant embryos and that RhoGEF2-Rho1 pathway components show strong specific genetic interactions with Nuf. We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200712036"xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/author | "Cao J."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/author | "Field C.M."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/author | "Sullivan W."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/author | "Albertson R."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/author | "Riggs B."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/pages | "301-313"xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/title | "Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization."xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/18644888 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18644888 |
| http://purl.uniprot.org/citations/18644888 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHL4-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFF8-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7T7-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K697-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7C4-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_C7LAH9-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EFD0-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EFT7-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EGC1-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |
| http://purl.uniprot.org/uniprot/#_A1ZAN6-mappedCitation-18644888 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18644888 |