DESCRIBE <http://purl.uniprot.org/citations/18647368>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18647368	http://www.w3.org/2000/01/rdf-schema#comment	" Background In red blood cells (RBCs) anionic phospholipids, such as phosphatidylserine, are present in the inner leaflet of the membrane bilayer. Exposure of phosphatidylserine occurs during senescence and during long-term storage of RBCs and is considered as the tag for removal from the circulation by macrophages. Lactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages that promotes the engulfment of phosphatidylserine-expressing apoptotic lymphocytes. This study investigates the role of lactadherin in the phagocytosis of phosphatidylserine-expressing RBCs. Study design and methods Transbilayer movement of phosphatidylserine was induced in RBCs either by storage beyond 30 days or by treatment with calcium ionophore A23187 and N-ethylmaleimide. Phosphatidylserine-expressing RBCs were incubated with phorbol ester-stimulated THP-1, and phagocytosis was determined by measuring the pseudoperoxidase activity of hemoglobin. The in vivo clearance of phosphatidylserine-enriched RBCs was measured in lactadherin-deficient mice and in their littermate controls. Results Lactadherin promoted phagocytosis of phosphatidylserine-expressing RBCs by macrophages in a concentration-dependent manner. Splenic macrophages from lactadherin-deficient mice had diminished capacity to phagocytose phosphatidylserine-expressing RBCs. The life span of RBCs in lactadherin-deficient mice was similar to wild-type littermate controls in vivo. However, when an excess of phosphatidylserine-expressing RBCs were infused, there was only a mild impairment in the clearance in lactadherin-deficient mice compared to wild-type littermate controls. Conclusion These results show that clearance of phosphatidylserine-expressing RBCs is not diminished in a significant way in lactadherin-deficient mice under physiologic conditions and suggest the presence of redundant pathways."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.org/dc/terms/identifier	"doi:10.1111/j.1537-2995.2008.01841.x"xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/author	"Nagata S."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/author	"Guchhait P."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/author	"Dasgupta S.K."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/author	"Thiagarajan P."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/author	"Abdel-Monem H."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/name	"Transfusion"xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/pages	"2370-2376"xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/title	"Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cells."xsd:string
http://purl.uniprot.org/citations/18647368	http://purl.uniprot.org/core/volume	"48"xsd:string
http://purl.uniprot.org/citations/18647368	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18647368
http://purl.uniprot.org/citations/18647368	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18647368
http://purl.uniprot.org/uniprot/#_A0A0U1RNV7-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_A0A8Q3SIZ9-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_B4E396-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_B3KTQ2-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_H0YKB5-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_P21956-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_Q08431-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_Q3TDU5-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/#_Q9QWQ1-mappedCitation-18647368	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18647368
http://purl.uniprot.org/uniprot/Q3TDU5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/18647368