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http://purl.uniprot.org/citations/18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18648372http://www.w3.org/2000/01/rdf-schema#comment"Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.org/dc/terms/identifier"doi:10.1038/sj.bjc.6604474"xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Roberts D."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Dive C."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"O'Dwyer S.T."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Stratford I.J."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Renehan A.G."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Saunders M.P."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Cawthorne C."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Armstrong G.R."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/author"Seenath M.M."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/name"Br J Cancer"xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/pages"459-463"xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/title"Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer."xsd:string
http://purl.uniprot.org/citations/18648372http://purl.uniprot.org/core/volume"99"xsd:string
http://purl.uniprot.org/citations/18648372http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18648372
http://purl.uniprot.org/citations/18648372http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18648372
http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18648372
http://purl.uniprot.org/uniprot/#_B3KT21-mappedCitation-18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18648372
http://purl.uniprot.org/uniprot/#_A8ASI8-mappedCitation-18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18648372
http://purl.uniprot.org/uniprot/#_A0A2P1N6U0-mappedCitation-18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18648372
http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18648372
http://purl.uniprot.org/uniprot/#_B1PL87-mappedCitation-18648372http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18648372