| http://purl.uniprot.org/citations/18650481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18650481 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic variants may increase susceptibility to both diabetes and kidney disease. Whether known diabetes-associated variants in the transcription factor 7-like 2 (TCF7L2) gene are associated with chronic kidney disease (CKD) progression and markers of kidney function is unknown. Participants of the Atherosclerosis Risk in Communities Study (ARIC; n = 11,061 self-identified white and n = 4014 black), Framingham Heart Offspring Cohort (FHS; n = 2468), and Heredity and Phenotype Intervention Heart Study (HAPI; n = 861) were genotyped at five (ARIC) and two (FHS) common TCF7L2 variants. The diabetes-conferring risk alleles at rs7903146 and rs7901695 were significantly associated with CKD progression among ARIC participants overall and among those without baseline diabetes. The overall adjusted hazard ratios per rs7903146 T allele were 1.17 (95% confidence interval [CI] 1.04 to 1.32) for white individuals and 1.20 (95% CI 1.03 to 1.41) for black individuals. Similarly, the overall hazard ratios per rs7901695 C allele were 1.19 (95% CI 1.06 to 1.34) for white individuals and 1.27 (95% CI 1.09 to 1.48) for black individuals. The FHS cohort supported these results: The rs7903146 T allele was significantly associated with lower estimated GFR (P = 0.01) and higher cystatin C (P = 0.004) in adjusted analyses overall and among those without diabetes. In the HAPI cohort, the rs7901695 C allele was significantly associated with lower estimated GFR in adjusted analyses (P = 0.049), as were several variants upstream and downstream of TCF7L2 (P < 0.003). No identified variant in the ARIC or FHS cohorts was associated with albuminuria. In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2007121291"xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Florez J.C."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Rampersaud E."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Boerwinkle E."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Coresh J."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Fox C.S."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Hwang S.J."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Kottgen A."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Levy D."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Shuldiner A.R."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Kao W.H."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Meigs J.B."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Parsa A."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "North K.E."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/author | "Pankow J.S."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/pages | "1989-1999"xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/title | "TCF7L2 variants associate with CKD progression and renal function in population-based cohorts."xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18650481 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18650481 |
| http://purl.uniprot.org/citations/18650481 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18650481 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-18650481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18650481 |