| http://purl.uniprot.org/citations/18650830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18650830 | http://www.w3.org/2000/01/rdf-schema#comment | "A recent genome-wide association study (GWAS) conducted by the International Multiple Sclerosis Genetics Consortium (IMSGC) identified a number of putative MS susceptibility genes. Here we have performed a replication study in 1134 Australian MS cases and 1265 controls for 17 risk-associated single nucleotide polymorphisms (SNPs) reported by the IMSGC. Of 16 SNPs that passed quality control filters, four, each corresponding to a different non-human leukocyte antigen (HLA) gene, were associated with disease susceptibility: KIAA0350 (rs6498169) P=0.001, IL2RA (rs2104286) P=0.033, RPL5 (rs6604026) P=0.041 and CD58 (rs12044852) P=0.042. There was no association (P=0.58) between rs6897932 in the IL7R gene and the risk of MS. No interactions were detected between the replicated IMSGC SNPs and HLA-DRB1*15, gender, disease course, disease progression or age-at-onset. We used a novel Bayesian approach to estimate the extent to which our data increased or decreased evidence for association with the six most-associated IMSGC loci. These analyses indicated that even modest P-values, such as those reported here, can contribute markedly to the posterior probability of 'true' association in replication studies. In conclusion, these data provide support for the involvement of four non-HLA genes in the pathogenesis of MS, and combined with previous data, increase to genome-wide significance (P=3 x 10(-8)) evidence of an association between KIAA0350 and risk of disease."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2008.59"xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Foote S.J."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Field J."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Chapman C."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Bahlo M."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Speed T.P."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Johnson L.J."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Taylor B.V."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Perera D."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Tait B.D."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Varney M.D."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Butzkueven H."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Kilpatrick T.J."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Marriott M."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Rubio J.P."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Stankovich J."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/author | "Tubridy N."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/pages | "624-630"xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/title | "Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians."xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18650830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18650830 |