| http://purl.uniprot.org/citations/18653469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18653469 | http://www.w3.org/2000/01/rdf-schema#comment | "Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, yet only a fraction of infected persons develop cancer. One H. pylori constituent that augments disease risk is the cytotoxin-associated gene (cag) pathogenicity island, which encodes a secretion system that translocates bacterial effector molecules into host cells. Matrix metalloproteinase (MMP)-7, a member of a family of enzymes with tumor-initiating properties, is overexpressed in premalignant and malignant gastric lesions, and H. pylori cag(+) strains selectively increase MMP-7 protein levels in gastric epithelial cells in vitro and in vivo. We now report that H. pylori-mediated mmp-7 induction is transcriptionally regulated via aberrant activation of p120-catenin (p120), a component of adherens junctions. H. pylori increases mmp-7 mRNA levels in a cag- and p120-dependent manner and induces translocation of p120 to the nucleus in vitro and in a novel ex vivo gastric gland culture system. Nuclear translocation of p120 in response to H. pylori relieves Kaiso-mediated transcriptional repression of mmp-7, which is implicated in tumorigenesis. These results indicate that selective and coordinated induction of mmp-7 expression by H. pylori cag(+) isolates may explain in part the augmentation in gastric cancer risk associated with these strains."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-03-0283"xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Peek R.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Wessler S."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Israel D.A."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Reynolds A.B."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Romero-Gallo J."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "O'Brien D.P."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Weydig C."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Fingleton B."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Wroblewski L.E."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Krishna U.S."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/author | "Ogden S.R."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/pages | "4110-4121"xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/title | "p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7."xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18653469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18653469 |
| http://purl.uniprot.org/citations/18653469 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18653469 |
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| http://purl.uniprot.org/uniprot/#_Q53GF1-mappedCitation-18653469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18653469 |
| http://purl.uniprot.org/uniprot/#_L8E7W8-mappedCitation-18653469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18653469 |