| http://purl.uniprot.org/citations/18653716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18653716 | http://www.w3.org/2000/01/rdf-schema#comment | "We examine the pathways involved in the luteinizing hormone receptor (LHR)-dependent activation of the epidermal growth factor (EGF) network using cocultures of LHR-positive granulosa cells and LHR-negative test cells expressing an EGF receptor (EGFR)-green fluorescent protein fusion protein. Activation of the LHR in granulosa cells results in the release of EGF-like growth factors that are detected by measuring the phosphorylation of the EGFR-green fluorescent protein expressed only in the LHR-negative test cells. Using neutralizing antibodies and real-time PCR, we identified epiregulin as the main EGF-like growth factor produced upon activation of the LHR expressed in immature rat granulosa cells, and we show that exclusive inhibition or activation of the ERK1/2 cascade in granulosa cells prevents or enhances epiregulin release, respectively, with little or no effect on epiregulin expression. These results show that the LHR-stimulated ERK1/2 pathway stimulates epiregulin release."xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2008-0618"xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/author | "Ascoli M."xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/author | "Andric N."xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/pages | "5549-5556"xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/title | "The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells."xsd:string |
| http://purl.uniprot.org/citations/18653716 | http://purl.uniprot.org/core/volume | "149"xsd:string |
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