| http://purl.uniprot.org/citations/18655774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18655774 | http://www.w3.org/2000/01/rdf-schema#comment | "Pleomorphic adenoma gene like-2 (PLAGL2), a developmentally regulated and stress inducible zinc finger protein can be post-translationally modified by small ubiquitin-like modifier peptide (SUMO-1); and SUMOylation attenuates PLAGL2 activity on the interactive promoter. Since PLAGL2 was a transactivator of the surfactant protein-C (SP-C) promoter, we hypothesized that SUMOylation down-regulated PLAGL2-activated SP-C promoter activity. Unexpectedly, the SUMO-conjugating enzyme Ubc9 enhanced, rather than reduced, PLAGL2 activated promoter activity but did not affect TTF-1 activation of the promoter. Ubc9 mutant (Ubc9-C93S) defective in SUMO-conjugating activity also enhanced PLAGL2-driven promoter activity suggesting that the stimulatory effect of Ubc9 on SP-C promoter activation was independent of its enzymatic function. PLAGL2 mutants without the K250 and/or K269 SUMOylation sites did not further improve PLAGL2 programmed transcription nor did they abolish Ubc9 enhanced promoter activity supporting the SUMOylation-independent mechanism. Chromatin immunoprecipitation (ChIP) assay demonstrated the association of PLAGL2 and Ubc9 with the SP-C promoter in vivo. Taken together, our data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity."xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.07.064"xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/author | "Yang Y.S."xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/author | "Yang M.C."xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/author | "Weissler J.C."xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/pages | "570-575"xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/title | "Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation."xsd:string |
| http://purl.uniprot.org/citations/18655774 | http://purl.uniprot.org/core/volume | "374"xsd:string |
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