| http://purl.uniprot.org/citations/18657639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18657639 | http://www.w3.org/2000/01/rdf-schema#comment | "Among the different cellular surveillance mechanisms in charge to prevent production of faulty gene products, nonsense-mediated mRNA decay (NMD) represents a translation-dependent posttranscriptional process that selectively recognizes and degrades mRNAs whose open reading frame (ORF) is truncated by a premature translation termination codon (PTC, also called "nonsense codon"). In doing so, NMD protects the cell from accumulating C-terminally truncated proteins with potentially deleterious functions. Transcriptome profiling of NMD-deficient yeast, Drosophila, and human cells revealed that 3-10% of all mRNA levels are regulated (directly or indirectly) by NMD, indicating an important role of NMD in gene regulation that extends beyond quality control [J. Rehwinkel, J. Raes, E. Izaurralde, Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors, Trends Biochem. Sci. 31 (2006) 639-646.[1]]. In this review, we focus on recent results from different model organisms that indicate an evolutionarily conserved mechanism for PTC identification."xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2008.06.012"xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/author | "Muhlemann O."xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/author | "Eberle A.B."xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/author | "Stalder L."xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/author | "Zamudio Orozco R."xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/pages | "538-549"xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/title | "Recognition and elimination of nonsense mRNA."xsd:string |
| http://purl.uniprot.org/citations/18657639 | http://purl.uniprot.org/core/volume | "1779"xsd:string |
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