| http://purl.uniprot.org/citations/18658164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18658164 | http://www.w3.org/2000/01/rdf-schema#comment | "Schizophrenia is a complex mental disorder with a fairly high degree of heritability. Although the causes of schizophrenia remain unclear, it is now widely accepted that it is a neurodevelopmental and neurodegenerative disorder involving disconnectivity and disorder of the synapses. Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene involved in neurodevelopment, including maturation of the cerebral cortex. To identify other susceptibility genes for schizophrenia, we screened for DISC1-interacting molecules [NudE-like (NUDEL), Lissencephaly-1 (LIS1), 14-3-3epsilon (YWHAE), growth factor receptor bound protein 2 (GRB2) and Kinesin family 5A of Kinesen1 (KIF5A)], assessing a total of 25 tagging single-nucleotide polymorphisms (SNPs) in a Japanese population. We identified a YWHAE SNP (rs28365859) that showed a highly significant difference between case and control samples, with higher minor allele frequencies in controls (P(allele) = 1.01 x 10(-5) and P(genotype) = 4.08 x 10(-5) in 1429 cases and 1728 controls). Both messenger RNA transcription and protein expression of 14-3-3epsilon were also increased in the lymphocytes of healthy control subjects harboring heterozygous and homozygous minor alleles compared with homozygous major allele subjects. To further investigate a potential role for YWHAE in schizophrenia, we studied Ywhae(+/-) mice in which the level of 14-3-3epsilon protein is reduced to 50% of that in wild-type littermates. These mice displayed weak defects in working memory in the eight-arm radial maze and moderately enhanced anxiety-like behavior in the elevated plus-maze. Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddn217"xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Inada T."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Kaibuchi K."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Toyo-oka K."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Wynshaw-Boris A."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Takao K."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Ozaki N."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Iwata N."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Miyakawa T."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Taya S."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Ujike H."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Hikita T."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/author | "Uraguchi-Asaki J."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/pages | "3212-3222"xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/title | "Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/18658164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18658164 |
| http://purl.uniprot.org/citations/18658164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18658164 |
| http://purl.uniprot.org/uniprot/#_B4DKG6-mappedCitation-18658164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18658164 |
| http://purl.uniprot.org/uniprot/#_D6REF3-mappedCitation-18658164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18658164 |