| http://purl.uniprot.org/citations/18660751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18660751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18660751 | http://www.w3.org/2000/01/rdf-schema#comment | "We have recently identified a new form of post-translational regulation of BACE1 (beta-site amyloid precursor protein (APP)-cleaving enzyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid beta-peptide (Abeta). Specifically, BACE1 is transiently acetylated on seven lysine residues in the lumen of the endoplasmic reticulum/endoplasmic reticulum-Golgi intermediate compartment (ER/ERGIC). The acetylated intermediates of the nascent protein are able to reach the Golgi apparatus, whereas the non-acetylated ones are retained and degraded in a post-ER compartment. Here, we report that the serine protease PCSK9 (proprotein convertase subtilisin kexin type 9) contributes to the disposal of non-acetylated BACE1. Both overexpression and small interfering RNA-mediated downregulation of PCSK9 affected the levels of BACE1. The downregulation of PCSK9 affected the levels of the loss-of-acetylation mutants (BACE1(Ala) and BACE1(Arg)) but not those of the gain-of-acetylation mutant (BACE1(Gln)). In addition, Pcsk9(-/-) mice showed increased levels of BACE1 and Abeta in the brain. Finally, we found that nascent low-density lipoprotein receptor, a known substrate of PCSK9, is also acetylated."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2008.132"xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2008.132"xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/author | "Jonas M.C."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/author | "Jonas M.C."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/author | "Puglielli L."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/author | "Puglielli L."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/author | "Costantini C."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/author | "Costantini C."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/pages | "916-922"xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/pages | "916-922"xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/title | "PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/title | "PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1."xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18660751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18660751 |
| http://purl.uniprot.org/citations/18660751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18660751 |
| http://purl.uniprot.org/citations/18660751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18660751 |
| http://purl.uniprot.org/citations/18660751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18660751 |