| http://purl.uniprot.org/citations/18662544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18662544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18662544 | http://www.w3.org/2000/01/rdf-schema#comment | "To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large number of downstream genes that change expression in old age, including ugt-9, col-144, and sod-3. elt-5(RNAi) and elt-6(RNAi) worms have extended longevity, indicating that elt-3, elt-5, and elt-6 play an important functional role in the aging process. These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.05.044"xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.05.044"xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Johnson T.E."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Johnson T.E."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Jiang M."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Jiang M."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Budovskaya Y.V."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Budovskaya Y.V."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Southworth L.K."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Southworth L.K."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Tedesco P."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/author | "Tedesco P."xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/pages | "291-303"xsd:string |
| http://purl.uniprot.org/citations/18662544 | http://purl.uniprot.org/core/pages | "291-303"xsd:string |