| http://purl.uniprot.org/citations/18662546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18662546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18662546 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus of the brain that synchronizes countless subsidiary oscillators in peripheral tissues. The rhythm-generating mechanism is thought to rely on a feedback loop involving positively and negatively acting transcription factors. BMAL1 and CLOCK activate the expression of Period (Per) and Cryptochrome (Cry) genes, and once PER and CRY proteins accumulate to a critical level they form complexes with BMAL1-CLOCK heterodimers and thereby repress the transcription of their own genes. Here, we show that SIRT1, an NAD(+)-dependent protein deacetylase, is required for high-magnitude circadian transcription of several core clock genes, including Bmal1, Rorgamma, Per2, and Cry1. SIRT1 binds CLOCK-BMAL1 in a circadian manner and promotes the deacetylation and degradation of PER2. Given the NAD(+) dependence of SIRT1 deacetylase activity, it is likely that SIRT1 connects cellular metabolism to the circadian core clockwork circuitry."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.06.050"xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.06.050"xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Reinke H."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Reinke H."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Gatfield D."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Gatfield D."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Schibler U."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Schibler U."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Asher G."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Asher G."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Dibner C."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Dibner C."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Kreppel F."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Kreppel F."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Mostoslavsky R."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Mostoslavsky R."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Stratmann M."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/author | "Stratmann M."xsd:string |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18662546 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |