| http://purl.uniprot.org/citations/18663336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18663336 | http://www.w3.org/2000/01/rdf-schema#comment | "Background/aimsSlc26a7 is a member of a family of anion transport proteins, Solute-Linked Carrier 26 (Slc26). Slc26a7, which can mediate Cl-/HCO3-exchange, is expressed in the acid-secreting, A-intercalated cells of the kidney collecting duct. On the basolateral side of the A-intercalated cells, Slc26a7 co-localizes with the anion exchanger 1 (AE1), a Cl-/HCO3-exchanger that mediates bicarbonate reabsorption in the collecting duct.MethodsTo test if Slc26a7 is involved in acid-base regulation, as its localization and function suggest, we examined the effect of acid loading and deletion of AE1 on Slc26a7 expression with quantitative real-time RT-PCR and Western blotting.ResultsFour days of acid loading increased Slc26a7 mRNA expression in the kidney inner medulla by 57% (n = 6 acid loaded vs. n = 6 control rats; p < 0.001), whereas mRNA expression in the outer medulla and the cortex did not change. Western blotting analysis demonstrated increased Slc26a7 protein expression in both outer (140%) and inner medulla (50%) in acid-loaded animals (n = 3) compared to controls (n = 3; p < 0.05). The expression of Slc26a7 mRNA was increased by 66% in the kidneys of AE1 knockout mice (n = 5) compared to the wild types (n = 5, p < 0.001). The increase in Slc26a7 mRNA correlated with a twofold increase in protein expression (p < 0.05).ConclusionWe suggest that the increase in Slc26a7 expression caused by acid challenge and deletion of AE1 represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney."xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.org/dc/terms/identifier | "doi:10.1159/000145465"xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/author | "Petrovic S."xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/name | "Nephron Physiol"xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/pages | "p29-35"xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/title | "Increased acid load and deletion of AE1 increase Slc26a7 expression."xsd:string |
| http://purl.uniprot.org/citations/18663336 | http://purl.uniprot.org/core/volume | "109"xsd:string |
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