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| http://purl.uniprot.org/citations/18664530 | http://www.w3.org/2000/01/rdf-schema#comment | "The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1(+)CD3(-)) in the murine liver whose function was currently unknown. In naïve animals, CD11c(+) liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c(-) liver NK cells. During the innate response to adenovirus infection, CD11c(+) NK cells were the more common IFN-gamma-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-gamma production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c(+) NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0408256"xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "Nguyen H.M."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "DeMatteo R.P."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "Plitas G."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "Pillarisetty V.G."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "Burt B.M."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "Bamboat Z.M."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/author | "Stableford J.A."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/pages | "1039-1046"xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/title | "CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis."xsd:string |
| http://purl.uniprot.org/citations/18664530 | http://purl.uniprot.org/core/volume | "84"xsd:string |
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