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http://purl.uniprot.org/citations/18665079http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18665079http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate change of G[alpha]i2, G[alpha]q mRNA, and their proteins in severe acute pancreatitis (SAP) and BN52021 effects.

Methods

Rats were assigned into negative-controlled group (NC), SAP-modeled group (SAP), and BN52051-remedial group (BN). Each group was assigned into 6 subgroups at different time points. G[alpha]i2, G[alpha]q mRNA, and their proteins were determined.

Results

In the SAP group, G[alpha]i2 at 12 and 24 hours and G[alpha]q at 1 and 6 hours were remarkably higher than those in the NC group; in the BN Group, G[alpha]i2 is not remarkably different from that in the SAP group, but G[alpha]q at 1 and 6 hours was lower than those in the SAP group (P < 0.01), and G[alpha]i2 at 12 hours was higher than that in the NC group (P < 0.05), but G[alpha]q was not remarkably different from that in the NC group; in the SAP group, G[alpha]i2 and G[alpha]q proteins were higher than those in the NC group (P < 0.05); in the BN group, G[alpha]i2 proteins at 6, 12, and 24 hours and G[alpha]q proteins were lower than those in the SAP group (P < 0.05), and G[alpha]i2 and G[alpha]q proteins at each time phase point except 24 hours were higher than those in the NC group (P < 0.05).

Conclusions

G[alpha]i2, G[alpha]q mRNA, and their proteins in SAP increase. BN52021 decreases G[alpha]i2 and G[alpha]q."xsd:string
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http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/author"Hu C.X."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/author"Di Y."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/author"Zhao Z.L."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/author"Fang J.M."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/author"Liu L.R."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/author"Xia S.H."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/name"Pancreas"xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/pages"170-175"xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/title"G[alpha]i2 and G[alpha]q expression change in pancreatic tissues and BN52021 effects in rats with severe acute pancreatitis."xsd:string
http://purl.uniprot.org/citations/18665079http://purl.uniprot.org/core/volume"37"xsd:string
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