| http://purl.uniprot.org/citations/18667528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18667528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18667528 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in yeast. mRNA export factors such as Thp1-Sac3 also affect genome integrity, but their mutations have other phenotypes different from those of THO/TREX. Sus1 is a novel component of SAGA transcription factor that also associates with Thp1-Sac3, but little is known about its effect on genome instability and transcription. Here we show that Thp1, Sac3, and Sus1 form a functional unit with a role in mRNP biogenesis and maintenance of genome integrity that is independent of SAGA. Importantly, the effects of ribozyme-containing transcription units, RNase H, and the action of human activation-induced cytidine deaminase on transcription and genome instability are consistent with the possibility that R-loops are formed in Thp1-Sac3-Sus1-Cdc31 as in THO mutants. Our data reveal that Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process that provides a feedback mechanism for the control of transcription and the preservation of genetic integrity of transcribed DNA regions."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-04-0355"xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-04-0355"xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Huertas P."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Huertas P."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Gonzalez-Aguilera C."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Gonzalez-Aguilera C."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Tous C."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Tous C."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Luna R."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Luna R."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Gomez-Gonzalez B."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/author | "Gomez-Gonzalez B."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/pages | "4310-4318"xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/pages | "4310-4318"xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/title | "The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability."xsd:string |
| http://purl.uniprot.org/citations/18667528 | http://purl.uniprot.org/core/title | "The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability."xsd:string |