| http://purl.uniprot.org/citations/18668043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18668043 | http://www.w3.org/2000/01/rdf-schema#comment | "The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons). However, the intracellular mechanisms triggered by ghrelin to alter NPY/AgRP neuronal activity are poorly understood. Here we show that ghrelin initiates robust changes in hypothalamic mitochondrial respiration in mice that are dependent on uncoupling protein 2 (UCP2). Activation of this mitochondrial mechanism is critical for ghrelin-induced mitochondrial proliferation and electric activation of NPY/AgRP neurons, for ghrelin-triggered synaptic plasticity of pro-opiomelanocortin-expressing neurons, and for ghrelin-induced food intake. The UCP2-dependent action of ghrelin on NPY/AgRP neurons is driven by a hypothalamic fatty acid oxidation pathway involving AMPK, CPT1 and free radicals that are scavenged by UCP2. These results reveal a signalling modality connecting mitochondria-mediated effects of G-protein-coupled receptors on neuronal function and associated behaviour."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07181"xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Friedman J.M."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Shulman G.I."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Liu Z.W."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Horvath T.L."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Diano S."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Gao X.B."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Tschop M.H."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Coppola A."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Cline G."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Andrews Z.B."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Borok E."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Shanabrough M."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Erion D.M."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/author | "Walllingford N."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/pages | "846-851"xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/title | "UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals."xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://purl.uniprot.org/core/volume | "454"xsd:string |
| http://purl.uniprot.org/citations/18668043 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18668043 |
| http://purl.uniprot.org/citations/18668043 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18668043 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVC9-mappedCitation-18668043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18668043 |