| http://purl.uniprot.org/citations/18677094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18677094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18677094 | http://www.w3.org/2000/01/rdf-schema#comment | "IkappaB kinase (IKK), the pivotal kinase in signal-dependent activation of nuclear factor-kappaB (NF-kappaB), is composed of multiple protein components, including IKK alpha/beta/gamma core subunits. To investigate the regulation of the IKK complex, we immunoaffinity purified the IKK complex, and by MALDI-TOF mass spectrometry identified a splice variant of zinc finger protein 268 (ZNF268) as a novel IKK-interacting protein. Both the full-length and the spliced form of the ZNF268 protein were detected in a variety of mammalian tissues and cell lines. The genes were cloned and expressed by in vitro transcription/translation. Several deletion derivatives, such as KRAB domain (KRAB) on its own, the KRAB/spacer/4-zinc fingers (zF4), and the spacer/ 4-zinc fingers (zS4), were ectopically expressed in mammalian cells and exhibited had different subcellular locations. The KRAB-containing mutants were restricted to the nucleus, while zS4 was localized in the cytosol. TNF-alpha-induced NF-kappaB activation was examined using these mutants and only zS4 was found to stimulate activation. Collectively, the results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Song H.J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Song H.J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Lee K.J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Lee K.J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Seo J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Seo J."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Suh J.W."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Suh J.W."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kang S.W."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kang S.W."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kim H.I."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kim H.I."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Song I.S."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Song I.S."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kang D.H."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Kang D.H."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Chun J.N."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Chun J.N."xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Lee K.J.'"xsd:string |
| http://purl.uniprot.org/citations/18677094 | http://purl.uniprot.org/core/author | "Lee K.J.'"xsd:string |