| http://purl.uniprot.org/citations/18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18679426 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation is an important cancer risk factor but the molecular pathways linking inflammation and cancer are incompletely understood. The transcription factor c-Jun/AP-1 (activator protein 1) is involved in inflammatory responses and tumorigenesis and has been proposed as an essential mediator of oncogenic beta-catenin signaling in the intestine. Here, we examined the functions of c-Jun in two distinct mouse models of conditional and intestine-specific activation of beta-catenin. c-Jun is strongly expressed in the small intestine of mutant mice. However, beta-catenin-dependent cell proliferation is surprisingly not affected in mice lacking c-jun in intestinal epithelium, suggesting that c-Jun is not an essential immediate target of beta-catenin signaling in the small intestine. To examine the functions of Jun and Fos proteins during inflammation and cancer in the colon, colitis-associated tumors were induced chemically in the respective knockout mice. Tumors were characterized by activated beta-catenin and strongly expressed c-Jun and JunB. However, tumorigenesis was not affected by inactivation of c-Jun in either intestinal epithelium or myeloid cells. Moreover, tumorigenesis was not altered in mice lacking junB, junD, c-fos, fra-1 or fra-2, suggesting that inhibition of c-Jun or other single AP-1 proteins is not a determining factor in colitis-associated cancer in mice."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2008.211"xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/author | "Wagner E.F."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/author | "Kudo H."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/author | "Gresh L."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/author | "Hasselblatt P."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/author | "Guinea-Viniegra J."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/pages | "6102-6109"xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/title | "The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice."xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18679426 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18679426 |
| http://purl.uniprot.org/citations/18679426 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18679426 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_D3YUH4-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-18679426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18679426 |