| http://purl.uniprot.org/citations/18682402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18682402 | http://www.w3.org/2000/01/rdf-schema#comment | "FBI-1 (Pokemon/ZBTB7A) is a proto-oncogenic transcription factor of the BTB/POZ (bric-à-brac, tramtrack, and broad complex and pox virus zinc finger) domain family. Recent evidence suggested that FBI-1 might be involved in adipogenic gene expression. Coincidentally, expression of FBI-1 and fatty-acid synthase (FASN) genes are often increased in cancer and immortalized cells. Both FBI-1 and FASN are important in cancer cell proliferation. SREBP-1 is a major regulator of many adipogenic genes, and FBI-1 and SREBP-1 (sterol-responsive element (SRE)-binding protein 1) interact with each other directly via their DNA binding domains. FBI-1 enhanced the transcriptional activation of SREBP-1 on responsive promoters, pGL2-6x(SRE)-Luc and FASN gene. FBI-1 and SREBP-1 synergistically activate transcription of the FASN gene by acting on the proximal GC-box and SRE/E-box. FBI-1, Sp1, and SREBP-1 can bind to all three SRE, GC-box, and SRE/E-box. Binding competition among the three transcription factors on the GC-box and SRE/E-box appears important in the transcription regulation. FBI-1 is apparently changing the binding pattern of Sp1 and SREBP-1 on the two elements in the presence of induced SREBP-1 and drives more Sp1 binding to the proximal promoter with less of an effect on SREBP-1 binding. The changes induced by FBI-1 appear critical in the synergistic transcription activation. The molecular mechanism revealed provides insight into how proto-oncogene FBI-1 may attack the cellular regulatory mechanism of FASN gene expression to provide more phospholipid membrane components needed for rapid cancer cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m802477200"xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Park H."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Lee C.E."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Kim M.H."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Kim Y.R."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Hur M.W."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Choi W.I."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Osborne T.F."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Jeon B.N."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/author | "Koh D.I."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/pages | "29341-29354"xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/title | "Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)."xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18682402 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18682402 |
| http://purl.uniprot.org/citations/18682402 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18682402 |
| http://purl.uniprot.org/uniprot/#_B4DGV9-mappedCitation-18682402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18682402 |
| http://purl.uniprot.org/uniprot/#_A8MTU8-mappedCitation-18682402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18682402 |
| http://purl.uniprot.org/uniprot/#_B3KR77-mappedCitation-18682402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18682402 |