| http://purl.uniprot.org/citations/18682702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18682702 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast transcription factor Ste12 controls both mating and filamentation pathways. Upon pheromone induction, the mitogen-activated protein kinases, Fus3 and Kss1, activate Ste12 by relieving the repression of two functionally redundant Ste12 inhibitors, Dig1 and Dig2. Mating genes are controlled by the Ste12/Dig1/Dig2 complex through Ste12-binding sites, whereas filamentation genes are regulated by the Tec1/Ste12/Dig1 complex through Tec1-binding sites. The two Ste12 complexes are mutually exclusive. During pheromone response, Tec1 is degraded upon phosphorylation by Fus3, preventing cross-activation of the filamentation pathway. Here, we show that a stable Tec1 also impairs the induction of mating genes. A mathematical model is developed to capture the dynamic formation of the two Ste12 complexes and their interactions with pathway-specific promoters. By model simulations and experimentation, we show that excess Tec1 can impair the mating transcriptional output because of its ability to sequester Ste12, and because of a novel function of Dig2 for the transcription of mating genes. We suggest that Fus3-triggered Tec1 degradation is an important part of the transcriptional induction of mating genes during the pheromone response."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.org/dc/terms/identifier | "doi:10.1038/msb.2008.47"xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/author | "Chou S."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/author | "Nie Q."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/name | "Mol Syst Biol"xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/pages | "212"xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/title | "Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response."xsd:string |
| http://purl.uniprot.org/citations/18682702 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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