| http://purl.uniprot.org/citations/18683628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18683628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18683628 | http://www.w3.org/2000/01/rdf-schema#comment | "Different strategies have been developed to produce vaccines against Pasteurella multocida. The approach described herein involves overexpression on the bacterial cell surface of Fur-regulated IROMPs (iron-regulated outer-membrane proteins). Accordingly, the ability of fur mutants to promote heterologous protection was examined in a Swiss mouse animal model. Twofur mutants derived from P. multocida were isolated, one of which was also defective in the OmpH protein. In mice challenged with virulent P. multocida, outer-membrane protein (OMP) extracts of fur cells conferred the same protection as obtained with wild-type cells grown in iron-depleted medium. Total protection was achieved with 40 microg of OMP extract from the fur ompH mutant. Mice administered heat-inactivated fur ompH cells were 60% cross-protected. The presence of a galE mutation in these cells did not further increase the protection level. Additionally, cell disruption by sonication provoked a higher level of protection than conferred by heat-treated cells. Taken together, the results showed that P. multocida fur ompH cells offer a simple and suitable approach for cross-protecting animals against infection with P. multocida."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Barbe J."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Barbe J."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Bosch M."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Bosch M."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Llagostera M."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Llagostera M."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Bigas A."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Bigas A."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Badiola I."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Badiola I."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Garrido M.E."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/author | "Garrido M.E."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/name | "Int. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/name | "Int Microbiol"xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/pages | "17-24"xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/pages | "17-24"xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/title | "Heterologous protective immunization elicited in mice by Pasteurella multocida fur ompH."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/title | "Heterologous protective immunization elicited in mice by Pasteurella multocida fur ompH."xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/18683628 | http://purl.uniprot.org/core/volume | "11"xsd:string |