| http://purl.uniprot.org/citations/18684959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18684959 | http://www.w3.org/2000/01/rdf-schema#comment | "Toxoplasma gondii infects astrocytes, neurons and microglia cells in the CNS and, after acute encephalitis, persists within neurons. Robust astrocyte activation is a hallmark of Toxoplasma encephalitis (TE); however, the in vivo function of astrocytes is largely unknown. To study their role in TE we generated C57BL/6 GFAP-Cre gp130(fl/fl) mice (where GFAP is glial fibrillary acid protein), which lack gp130, the signal-transducing receptor for IL-6 family cytokines, in their astrocytes. In the TE of wild-type mice, the gp130 ligands IL-6, IL-11, IL-27, LIF, oncostatin M, ciliary neurotrophic factor, B cell stimulating factor, and cardiotrophin-1 were up-regulated. In addition, GFAP(+) astrocytes of gp130(fl/fl) control mice were activated, increased in number, and efficiently restricted inflammatory lesions and parasites, thereby contributing to survival from TE. In contrast, T. gondii-infected GFAP-Cre gp130(fl/fl) mice lost GFAP(+) astrocytes in inflammatory lesions resulting in an inefficient containment of inflammatory lesions, impaired parasite control, and, ultimately, a lethal necrotizing TE. Production of IFN-gamma and the IFN-gamma-induced GTPase (IGTP), which mediate parasite control in astrocytes, was even increased in GFAP-Cre gp130(fl/fl) mice, indicating that instead of the direct antiparasitic effect the immunoregulatory function of GFAP-Cre gp130(fl/fl) astrocytes was disturbed. Correspondingly, in vitro infected GFAP-Cre gp130(fl/fl) astrocytes inhibited the growth of T. gondii efficiently after stimulation with IFN-gamma, whereas neighboring noninfected and TNF-stimulated GFAP-Cre gp130(fl/fl) astrocytes became apoptotic. Collectively, these are the first experiments demonstrating a crucial function of astrocytes in CNS infection."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.4.2683"xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Mueller W."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Gutmann D.H."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Deckert M."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Brunn A."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Schluter D."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Drogemuller K."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Sakowicz-Burkiewicz M."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/author | "Helmuth U."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/pages | "2683-2693"xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/title | "Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis."xsd:string |
| http://purl.uniprot.org/citations/18684959 | http://purl.uniprot.org/core/volume | "181"xsd:string |
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