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http://purl.uniprot.org/citations/18687117http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18687117http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18687117http://www.w3.org/2000/01/rdf-schema#comment"

Background

As nuclear mediators of wnt/beta-catenin signaling, Lef/Tcf transcription factors play important roles in development and disease. Although it is well established, that the four vertebrate Lef/Tcfs have unique functional properties, most studies unite Lef-1, Tcf-1, Tcf-3 and Tcf-4 and reduce their function to uniformly transduce wnt/beta-catenin signaling for activating wnt target genes. In order to discriminate target genes regulated by XTcf-3 from those regulated by XTcf-4 or Lef/Tcfs in general, we performed a subtractive screen, using neuralized Xenopus animal cap explants.

Results

We identified cold-inducible RNA binding protein (CIRP) as novel XTcf-3 specific target gene. Furthermore, we show that knockdown of XTcf-3 by injection of an antisense morpholino oligonucleotide results in a general broadening of the anterior neural tissue. Depletion of XCIRP by antisense morpholino oligonucleotide injection leads to a reduced stability of mRNA and an enlargement of the anterior neural plate similar to the depletion of XTcf-3.

Conclusion

Distinct steps in neural development are differentially regulated by individual Lef/Tcfs. For proper development of the anterior brain XTcf-3 and the Tcf-subtype specific target XCIRP appear indispensable. Thus, regulation of anterior neural development, at least in part, depends on mRNA stabilization by the novel XTcf-3 target gene XCIRP."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.org/dc/terms/identifier"doi:10.1186/1471-213x-8-77"xsd:string
http://purl.uniprot.org/citations/18687117http://purl.org/dc/terms/identifier"doi:10.1186/1471-213x-8-77"xsd:string
http://purl.uniprot.org/citations/18687117http://purl.org/dc/terms/identifier"doi:10.1186/1471-213X-8-77"xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Wedlich D."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Wedlich D."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Fichtner D."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Fichtner D."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Gradl D."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Gradl D."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Kunz M."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"Kunz M."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"van Venrooy S."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/author"van Venrooy S."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/name"BMC Dev. Biol."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/name"BMC Dev. Biol."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/pages"77"xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/pages"77"xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/title"Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/title"Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus."xsd:string
http://purl.uniprot.org/citations/18687117http://purl.uniprot.org/core/volume"8"xsd:string
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