| http://purl.uniprot.org/citations/18691969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18691969 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranslational modification with small ubiquitin-related modifier, SUMO, is a widespread mechanism for rapid and reversible changes in protein function. Considering the large number of known targets, the number of enzymes involved in modification seems surprisingly low: a single E1, a single E2, and a few distinct E3 ligases. Here we show that autosumoylation of the mammalian E2-conjugating enzyme Ubc9 at Lys14 regulates target discrimination. While not altering its activity toward HDAC4, E2-25K, PML, or TDG, sumoylation of Ubc9 impairs its activity on RanGAP1 and strongly activates sumoylation of the transcriptional regulator Sp100. Enhancement depends on a SUMO-interacting motif (SIM) in Sp100 that creates an additional interface with the SUMO conjugated to the E2, a mechanism distinct from Ubc9 approximately SUMO thioester recruitment. The crystal structure of sumoylated Ubc9 demonstrates how the newly created binding interface can provide a gain in affinity otherwise provided by E3 ligases."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.05.022"xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Olsen J.V."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Sixma T.K."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "van Dijk W.J."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Fish A."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Johnson E.S."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Flotho A."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Knipscheer P."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Pichler A."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/author | "Klug H."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/pages | "371-382"xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/title | "Ubc9 sumoylation regulates SUMO target discrimination."xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/18691969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18691969 |
| http://purl.uniprot.org/citations/18691969 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18691969 |
| http://purl.uniprot.org/uniprot/#_P52948-mappedCitation-18691969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18691969 |
| http://purl.uniprot.org/uniprot/#_P56524-mappedCitation-18691969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18691969 |
| http://purl.uniprot.org/uniprot/#_A8CG34-mappedCitation-18691969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18691969 |
| http://purl.uniprot.org/uniprot/#_A8K503-mappedCitation-18691969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18691969 |
| http://purl.uniprot.org/uniprot/#_B0QYN7-mappedCitation-18691969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18691969 |