| http://purl.uniprot.org/citations/18692039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18692039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18692039 | http://www.w3.org/2000/01/rdf-schema#comment | "In somatic cells, untranslated mRNAs accumulate in cytoplasmic foci called processing bodies or P-bodies. P-bodies contain complexes that inhibit translation and stimulate mRNA deadenylation, decapping, and decay. Recently, certain P-body proteins have been found in germ granules, RNA granules specific to germ cells. We have investigated a possible connection between P-bodies and germ granules in Caenorhabditis elegans. We identify PATR-1, the C. elegans homolog of the yeast decapping activator Pat1p, as a unique marker for P-bodies in C. elegans embryos. We find that P-bodies are inherited maternally as core granules that mature differently in somatic and germline blastomeres. In somatic blastomeres, P-bodies recruit the decapping activators LSM-1 and LSM-3. This recruitment requires the LET-711/Not1 subunit of the CCR4-NOT deadenylase and correlates spatially and temporally with the onset of maternal mRNA degradation. In germline blastomeres, P-bodies are maintained as core granules lacking LSM-1 and LSM-3. P-bodies interact with germ granules, but maintain distinct dynamics and components. The maternal mRNA nos-2 is maintained in germ granules, but not in P-bodies. We conclude that P-bodies are distinct from germ granules, and represent a second class of RNA granules that behaves differently in somatic and germline cells."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2008.07.008"xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2008.07.008"xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Gallo C.M."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Gallo C.M."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Rasoloson D."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Rasoloson D."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Merritt C."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Merritt C."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Munro E."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/author | "Munro E."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/pages | "76-87"xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/pages | "76-87"xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/title | "Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/title | "Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/volume | "323"xsd:string |
| http://purl.uniprot.org/citations/18692039 | http://purl.uniprot.org/core/volume | "323"xsd:string |