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http://purl.uniprot.org/citations/18692475http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18692475http://www.w3.org/2000/01/rdf-schema#comment"Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in a more complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.org/dc/terms/identifier"doi:10.1016/j.cell.2008.07.009"xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Fan C."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Li N."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Hyman A.A."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Galli M."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Schlaitz A.L."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Bonneau R."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Vidal M."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Hill D.E."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Boxem M."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Hao T."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Roth F.P."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Drechsel D."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Dunker A.K."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Koller D."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"van den Heuvel S."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Piano F."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Iakoucheva L.M."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Lemmens I."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Tavernier J."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Gunsalus K.C."xsd:string
http://purl.uniprot.org/citations/18692475http://purl.uniprot.org/core/author"Devos M."xsd:string