http://purl.uniprot.org/citations/18692475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18692475 | http://www.w3.org/2000/01/rdf-schema#comment | "Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored this modular organization of proteins. We developed an experimental strategy to efficiently identify interaction domains and generated a domain-based interactome network for proteins involved in C. elegans early-embryonic cell divisions. Minimal interacting regions were identified for over 200 proteins, providing important information on their domain organization. Furthermore, our approach increased the sensitivity of the two-hybrid system, resulting in a more complete interactome network. This interactome modeling strategy revealed insights into C. elegans centrosome function and is applicable to other biological processes in this and other organisms."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.07.009"xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Fan C."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Galli M."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Schlaitz A.L."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Bonneau R."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Hao T."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Roth F.P."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Drechsel D."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Dunker A.K."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Koller D."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Piano F."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Iakoucheva L.M."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Lemmens I."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Tavernier J."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Gunsalus K.C."xsd:string |
http://purl.uniprot.org/citations/18692475 | http://purl.uniprot.org/core/author | "Devos M."xsd:string |