| http://purl.uniprot.org/citations/18694960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18694960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18694960 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer cells may evade immune surveillance as a result of defective antigen processing and presentation. In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon regulatory factor 1 (IRF-1). We show that unlike interferon signaling, which triggers the STAT1-mediated transcriptional activation of IRF-1, the ligation of CD40 in carcinomas induces the rapid upregulation of IRF-1 in a STAT1-independent but NF-kappaB-dependent manner. The transcriptional activation of IRF-1 is controlled largely by the recruitment of p65 (RelA) NF-kappaB to the IRF-1 promoter following the engagement of a TAK1/IkappaB kinase beta/IkappaBalpha signaling pathway downstream of CD40. NF-kappaB and de novo-synthesized IRF-1 converge to regulate the expression of genes involved in antigen processing and transport, as evident from the sequential recruitment of NF-kappaB and IRF-1 to the promoters of the genes encoding transporter for antigen processing 1 (TAP1), TAP2, tapasin, and low-molecular-mass polypeptides LMP2 and LMP10. Moreover, the RNA interference-mediated knockdown of IRF-1 reduced, whereas the inhibition of NF-kappaB abolished, the effects of CD40 on TAP1 and LMP2 upregulation in carcinoma cells. Collectively, these data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00611-08"xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00611-08"xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Thymiakou E."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Thymiakou E."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Eliopoulos A.G."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Eliopoulos A.G."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Kardassis D."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Kardassis D."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Knox P.G."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Knox P.G."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Kouraki M."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Kouraki M."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Moschonas A."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/author | "Moschonas A."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/pages | "6208-6222"xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/pages | "6208-6222"xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/title | "CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1."xsd:string |
| http://purl.uniprot.org/citations/18694960 | http://purl.uniprot.org/core/title | "CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1."xsd:string |