| http://purl.uniprot.org/citations/18694996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18694996 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoiesis strictly depends on signal transduction through the erythropoietin receptor (EpoR)-Janus kinase 2 (Jak2)-signal transducer and activator of transcription 5 (Stat5) axis, regulating proliferation, differentiation, and survival. The exact role of the transcription factor Stat5 in erythropoiesis remained puzzling, however, since the first Stat5-deficient mice carried a hypomorphic Stat5 allele, impeding full phenotypical analysis. Using mice completely lacking Stat5--displaying early lethality--we demonstrate that these animals suffer from microcytic anemia due to reduced expression of the antiapoptotic proteins Bcl-x(L) and Mcl-1 followed by enhanced apoptosis. Moreover, transferrin receptor-1 (TfR-1) cell surface levels on erythroid cells were decreased more than 2-fold on erythroid cells of Stat5(-/-) animals. This reduction could be attributed to reduced transcription of TfR-1 mRNA and iron regulatory protein 2 (IRP-2), the major translational regulator of TfR-1 mRNA stability in erythroid cells. Both genes were demonstrated to be direct transcriptional targets of Stat5. This establishes an unexpected mechanistic link between EpoR/Jak/Stat signaling and iron metabolism, processes absolutely essential for erythropoiesis and life."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-02-138339"xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Beug H."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Grebien F."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Moriggl R."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Gehart H."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Mullner E.W."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Kovacic B."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Kerenyi M.A."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Artaker M."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/author | "Schifrer M."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/pages | "3878-3888"xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/title | "Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1."xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18694996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18694996 |
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| http://purl.uniprot.org/uniprot/#_P63073-mappedCitation-18694996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18694996 |
| http://purl.uniprot.org/uniprot/#_P63085-mappedCitation-18694996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18694996 |