| http://purl.uniprot.org/citations/18695251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18695251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18695251 | http://www.w3.org/2000/01/rdf-schema#comment | "AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive regulator of p53 in response to genotoxic stresses. Depletion of AIMP2 increased resistance to DNA damage-induced apoptosis, and introduction of AIMP2 into AIMP2-deficient cells restored the susceptibility to apoptosis. Upon DNA damage, AIMP2 was phosphorylated, dissociated from the multi-tRNA synthetase complex, and translocated into the nuclei of cells. AIMP2 directly interacts with p53, thereby preventing MDM2-mediated ubiquitination and degradation of p53. Mutations in AIMP2, affecting its interaction with p53, hampered its ability to activate p53. Nutlin-3 recovered the level of p53 and the susceptibility to UV-induced cell death in AIMP2-deficient cells. This work demonstrates that AIMP2, a component of the translational machinery, functions as proapoptotic factor via p53 in response to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0800297105"xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0800297105"xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Park S.G."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Park S.G."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Chang S.-H."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Chang S.-H."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Cho M.-H."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Cho M.-H."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Han J.M."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Han J.M."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Choi S.J."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Choi S.J."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Hwang S.-K."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Hwang S.-K."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Oh Y.S."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Oh Y.S."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Park B.-J."xsd:string |
| http://purl.uniprot.org/citations/18695251 | http://purl.uniprot.org/core/author | "Park B.-J."xsd:string |